| S | Assembler source code (Unix) |
| S | Source code file (Scheme) |
| SAI | Encrypted video file (Integrated Sensors) |
| SAL | Datafile (SORITEC) |
| SAM | Document (AMI Professional) |
| SAM | Signed 8bit sample data file |
| SAR | Compressed archive (SAR) |
| SAV | Saved game file (Generic) |
| SAV | Backup file (Generic) |
| SAV | Configuration file (Generic) |
| SB | Raw Signed Byte (8bit) audio data |
| SBD | Storyboard data file (Storyboard Editor) |
| SBD | Data definition file (Superbase) |
| SBF | File data (Superbase) |
| SBI | Instrument file (Creative Labs SoundBlaster) |
| SBK | Bank file (Soundblaster)/EMU SoundFont v1.x (Creative Labs Soundfont 1.0) |
| SBL | Flash object (ShockWave) |
| SBP | Dml program file (Superbase 4) |
| SBP | Program file (Superbase) |
| SBQ | Query definition file (Superbase) |
| SBR | Support file (Source Browser) |
| SBT | Notes related to record data (Superbase 4 for Windows) |
| SBV | Form definition file (Superbase) |
| SB! | Locking file (Superbase) |
| SC | Pal script (Paradox) |
| SC | Display driver (Framework II) |
| SC2 | Schedule+ 7.0 file (Microsoft) |
| SC2 | SAS catalog (Windows 95/NT, OS/2, Mac) |
| SC3 | Saved game file (SIMM City 3000) |
| SC3 | Renamed dBase III screen mask file (dBase IV) |
| SC3 | Screen device driver (Harvard Graphics 3.0) |
| SC4 | Level file (Roller Coaster Tycoon) |
| SCA | Datafile (SCA) |
| SCC | Source Safe file (Microsoft) |
| SCC | Text file (Generic) |
| SCD | Slide image (Matrix/Imapro SCODL) |
| SCD | Object description language graphics (Scodl Scan Conversion) |
| SCD | Datafile (Microsoft Schedule+ 7.0) |
| SCF | Command file (Microsoft Windows Explorer) |
| SCF | Multimedia show (ScoreMaker) |
| SCF | Spell checker configuration file (Symphony) |
| SCH | Datafile (Microsoft Schedule+ 7.0) |
| SCH | Schematics file (ORCAD) |
| SCI | Inspire native format (ScanVec) |
| SCI | System configuration information file (Generic) |
| SCI | Fax document (SciFAX) |
| SCM | Scheme source code file (Generic) |
| SCM | Video game console ROM emulater file |
| SCN | Scene data file (TrueSpace2) |
| SCN | Screen file (Kermit) |
| SCO | High score file (Generic game file) |
| SCP | Dial-Up Networking Script |
| SCP | Script file (BITCOM) |
| SCR | Screensaver file (Microsoft Windows 9.x) |
| SCR | Fax image (Generic) |
| SCR | Debug source code (DOS Debug) |
| SCR | Screen snapshot file (dBase IV) |
| SCR | Screen snapshot file (Procomm Plus) |
| SCR | Screen font file (LocoScript) |
| SCT | SAS catalog (Dos) |
| SCT | CT bitmap (Scitex) |
| SCT | FoxPro forms (Microsoft) |
| SCT01 | SAS catalog (Unix) |
| SCV | CASmate Native format (ScanVec) |
| SCX | FoxPro forms (Microsoft) |
| SCX | Bitmap graphics (ColorRIX) |
| SCX | Chart (Stanford Chart) |
| SCX | Screen file (Microsoft FoxPro) |
| SCY | Security file (ReaGeniX) |
| SD | Audio (Sound Designer I) |
| SD2 | Flattened file/data fork (Sound Designer II) |
| SD2 | SAS database (Windows 95/NT OS/2, Mac) |
| SDA | File archive description (Fidonet Software Distribution Network) |
| SDC | Spreadsheet (Staroffice)(StarCalc) |
| SDD | Presentation file (Staroffice)(Starimpress) |
| SDF | System Data File Format - legacy Unisys (Sperry) format |
| SDI | Software distribution network information file |
| SDK | Floppy disk image (Roland) |
| SDL | Library file (SmartDraw) |
| SDN | Software distribution network compressed archive |
| SDP | Datafile (Cocreate SolidDesigner) |
| SDPC | Datafile (Cocreate SolidDesigner) |
| SDR | Drawing (SmartDraw) |
| SDS | Raw Midi Sample Dump Standard file |
| SDT | Template (SmartDraw) |
| SDV | Semicolon Divided Values file |
| SDW | Graphic file (Lotus WordPro) |
| SDW | Raw Signed DWord (32bit) data |
| SDX | Midi Sample Dump Standard files compacted by SDX |
| SEA | Self-expanding archive (used by Stuffit for Mac files and possibly by others) |
| SEC | Secret key ring file (PGP) |
| SEC | Secured animation file (Disney Animation Studio) |
| SED | Screen editor script files (SED) |
| SEL | Data file (Copy Books) |
| SEP | Tagged Image File Format (TIFF) bitmap |
| SEP | Printer seperator page (Generic) |
| SEQ | Animation file (Atari) |
| SEQ | Sequential instruction file (Bubble Chamber) |
| SES | Session file (Cool Edit) (common digital audio editor file ) |
| SES | Session information file (Clarion Modula-2) |
| SESSION | Internet Security Scanner file (ISS) |
| SET | Configuration file (1st Reader) |
| SET | Install driver sets (Symphony) |
| SET | Setup option file (Generic) |
| SET | Voice set files (Quartet) |
| SEW | Sewing program file (Generic) |
| SF | SoundFile format (IrCam) |
| SF | Wps attribute storage file (OS/2 WorkPlace Shell) |
| SF2 | SoundFont file (EMU version 2.0) |
| SF2 | Bank file (Creative Labs Soundfont 2.0)(Soundblaster) |
| SFD | Sound File Data (SoundStage) |
| SFI | Sound File Info (SoundStage) |
| SFI | Graphics file (SIS Framegrabber) |
| SFI | Printer font file (Hewlett-Packard Laser Jet Landscape) |
| SFI | Printer font file (Ventura Publisher) |
| SFK | Sound file (Sonic Foundry) |
| SFL | Pcl 4 bitmap font (LandScape) |
| SFL | Pcl 4 bitmap font (Ventura Publisher) |
| SFL | Pcl 4 bitmap font (Intellifont) |
| SFN | Font file (SPX) |
| SFP | Pcl bitmap font (Portrait) |
| SFP | Pcl bitmap font (Intellifont) |
| SFP | Pcl bitmap font (Ventura Publisher) |
| SFR | Sample Resource (Sonic Foundry) |
| SFS | Pcl 5 scalable font file (Intellifont) |
| SFT | Screen font (ChiWriter) |
| SFW | Mangled JPEG (Seattle Filmworks) |
| SFX | Self-extracting archive (RAR) |
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